The Minnesota Twins head to Oracle Park on Tuesday, September 22, 2026, for a 9:45 PM ET first pitch against the San Francisco Giants. Taj Bradley gets the start for Minnesota against Giants right-hander Anthony Molina in what shapes up as an intriguing late-season matchup on the West Coast. With the regular season winding down, every game carries weight, and the Twins need a sharp performance from their starter to steal a road win in one of baseball's most unique ballparks.

Twins at Giants: Pitching Matchup at Oracle Park

Taj Bradley draws the assignment for Minnesota. The right-hander will need to be dialed in against a Giants lineup that features some interesting pieces at the top. On the other side, Anthony Molina gets the nod for San Francisco. Neither pitcher has detailed stats available for this preview, so the matchup will need to speak for itself once the first pitch is thrown.

Oracle Park's dimensions and marine layer can play tricks on hitters and pitchers alike. Fly balls that would clear the wall in a hitter-friendly park sometimes die at the warning track here. Bradley will want to work efficiently and keep the Giants off the bases rather than relying on defense to bail him out in the quirky confines along McCovey Cove.

San Francisco Giants Starting Lineup

• Drew Gilbert, CF
• Jonah Cox, 2B
• Victor Bericoto, 1B
• Turner Hill, LF
• Bo Davidson, DH
• Shay Whitcomb, 3B
• Scott Bandura, RF
• Drew Cavanaugh, C
• Christian Koss, SS

Keys to Watch for Minnesota

Bradley's Command Early

The first time through the Giants order will tell you everything you need to know about how Minnesota's night is going to go. If Bradley can pound the strike zone and avoid deep counts, the Twins bullpen gets a breather. If he's battling his command from the first inning, it becomes a long night in San Francisco.

Minnesota's Offense Against Molina

The Twins lineup card isn't available for this preview, which makes it harder to project where the offense will come from. What Minnesota needs is patience at the plate against Molina early, work the count, and make the Giants bullpen earn it if Molina runs into trouble.

Managing the Late-Night West Coast Game

A 9:45 PM ET start is a grind for any Central Division team. Late-night West Coast games can flatten offenses that don't stay locked in. Minnesota will need to come out alert and not let the time zone become a factor by the middle innings.

Prediction

This one comes down to whether Taj Bradley can go deep enough into the game to keep Minnesota's bullpen fresh for what remains of the regular season schedule. The Giants have their own pieces, and Oracle Park is never an easy place to win. Expect a tight, low-scoring game. Twins 3, Giants 2 — Minnesota edges it out if Bradley delivers six solid innings.

Catch the game on Twins.TV Presented by Progressive or tune in on WCCO 830 AM or The Wolf 102.9 FM for radio coverage.